Preventive Effects of Ginger Extract and Nigella sativa Oil on Anxiety and Depression Behavior in Wistar Rats Exposed to Mercuric Chloride

Pharmacognosy Research,2022,14,1,1-4.DOI:10.5530/pres.14.1.1Published:December 2021Type:Original ArticleAuthors:Sabri Benkermiche, Samir Djemli, Meriem Haloui, Mohamed Lamine Benabed, and Abdelkrim Tahraoui Author(s) affiliations:Sabri Benkermiche1, Djemli1,*, Haloui2, Benabed1, Tahraoui1 1Applied Neuroendocrinology Laboratory, Department of Biology, Faculty Sciences, Badji Mokhtar Annaba University, Annaba, ALGERIA. 2Department Pharmacy, Medicine, University Batna 2, Abstract:Background: Mercuric chloride (HgCl2) is toxic to humans animals, usually causes systemic nerve damage. Aim: The aim this study evaluate the neuro-protective effects two medicinal plants rich in antioxidants against mercuric poisoning Wistar rats. Materials Methods: This an experimental conducted on twenty-five adult rats randomly divided into five groups each, untreated control group four are treated daily with Ginger extract (500 mg/kg/day) Nigella sativa oil (2ml/kg/day) for weeks. administration (4mg/kg/day) will be from second week experimentation three Results: results obtained showed by behavioral tests that inorganic mercury significantly increases state anxiety depression compared rats, while pre-treated can reduce damage these disorders. Conclusion: have a very important role neurobehavioral alterations induced toxicity. Keywords:Antioxidants, Anxiety, Depression, Chloride, Neuroprotection, Rats.View:PDF (278.54 KB) Full Text